Envafolimab With Chemotherapy and Simvastatin in Advanced Biliary Tract Cancer

Inclusion Criteria

• •Age : ≥18 years old.
• •Diagnosis : Histologically confirmed unresectable, locally advanced, or metastatic biliary tract adenocarcinoma (including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder cancer).
• •Prior Treatment :Treatment-naïve for unresectable/metastatic disease at initial diagnosis, OR Disease recurrence ≥6 months after curative surgery or adjuvant therapy.
• •Performance Status : ECOG PS 0 or 1.
• •Measurable Disease : At least one radiologically measurable lesion per RECIST 1.1 (tumor lesion ≥10 mm on CT scan, lymph node ≥15 mm in short axis).
• •Organ Function : No severe functional impairment of heart, lung, brain, or other vital organs.