Has a ≥4 week history of AjD as defined by DSM-5-TR with either depressed mood, or mixed anxiety and depressed mood confirmed by clinical interview with evidence that the AjD was instigated by one of the following medical illnesses (e.g., diagnosis, impact, management, recurrence, prognosis): Cancer, ALS, MS, PD or IPF
Is sufficiently ambulatory and capable of self care as necessary to complete study procedures
Has normal cognitive function
Is on stable use of antidepressants or psychotherapy, or is willing to delay use until the end of study
If female is not pregnant or planning to become pregnant. If male is not planning to make a partner pregnant
Is willing and able to comply with the conditions and requirements of the study
You may not be if
Has a significant risk of suicide
Has active or medical history of bipolar disorder, schizophrenia, schizoaffective disorder, psychotic disorder and/or borderline personality disorder, or first-degree family history of psychosis or bipolar disorder
Has active or a history of central nervous system malignancy
Has other medically significant conditions rendering unsuitability for the study
Has used or will need to use prohibited medications or therapies
Has a known sensitivity or intolerance to study intervention or potential rescue medications
