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The purpose of this study is to evaluate whether the measure of the optic nerve sheath is a reliable diagnostic marker for giant cell arteritis
Giant Cell Arteritis (GCA) is a vasculitis affecting large and medium-sized vessels. It predominantly occurs in women, with a sex ratio of 3:1, and mainly affects individuals around 70 years of age. GCA is a rare condition, with an incidence of approximately 10 cases per 100,000 people in France. Current recommendations suggest using imaging techniques and/or temporal artery biopsy (TAB) based on the clinical resources available. The key challenge in suspected cases of GCA is to establish a rapid diagnosis. It is important to note that false-negative imaging results may occur if corticosteroid treatment is initiated prior to imaging: after 3 days for PET-CT, 5 to 7 days for Doppler ultrasound, and up to 14 days for TAB. Diagnosing GCA is not always easy and depends on depends on the prompt performance of complementary examinations. Studies have shown that the optic nerve sheath is thickened on ultrasound in patients with GCA. In this context, the investigator aims to evaluate the measurement of the optic nerve sheath via ultrasound for diagnosing GCA. Ultrasound offers a faster, non-invasive, widely available, and cost-effective diagnostic tool.
Age
50 - No limit years
Sex
ALL
Healthy Volunteers
No
Rhumatology departement - Centre Hospitalier Aix en Provence
Aix-en-Provence, France
Rhumatology department - Centre Hospitalier Universitaire de Brest
Brest, France
Internal Medecine Department- CHU Caen
Caen, France
Internal Medicine and Clinical Immulogy department - Centre Hospitalier Universitaire de Dijon
Dijon, France
Internal Medicine and VascularMedecine Department - Centre Hospitalier Universitaire de Nantes
Nantes, France
Internal Medicine department - Hôpital Saint-Antoine
Paris, France
Rhumatology department - Hôpital Bichat
Paris, France
Rhumatology department - Hôpital NOVO - Pontoise site
Pontoise, France
Rhumatology department - Centre Hospitalier Universitaire de Tours
Tours, France
Start Date
September 4, 2025
Primary Completion Date
March 31, 2028
Completion Date
March 31, 2028
Last Updated
September 12, 2025
190
ESTIMATED participants
orbital ultrasound
DIAGNOSTIC_TEST
Lead Sponsor
Hôpital NOVO
NCT06887062
NCT06609668
Data Source & Attribution
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