This is an observational study, in which the main research question is to evaluate the risk of malignancies and serious infections among moderate/severe SLE patients who receive anifrolumab compared with a comparable population of moderate/severe SLE patients on standard of care who do not initiate anifrolumab.
Age
18–130
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
First prescription of anifrolumab in the study period (no anifrolumab prescription prior to index date): date of first anifrolumab prescription will be the index date
A minimum data availability of 12 months prior to index date
Age ≥18 years at index date
SLE severity: patients with moderate to severe SLE at index date
SLE activity: patients with at least a flare (uncontrolled SLE) in the 6 months prior to index date
You may not be if
A diagnosis of any malignancy prior to index date
A diagnosis of HIV/AIDS or congenital immunodeficiency prior to index date
Organ or bone marrow transplant procedure prior to index date
A diagnosis of serious infection in the previous 6 months
