Colchicine in Chronic Kidney Disease Patients

A total of 744 patients will be included (50% in each branch), and the follow-up time of the study will be three years. EXPLORATORY PARAMETERS * Analytical parameters in blood: * Hemogram: hemoglobin, erythrocyte sedimentation rate. * Biochemistry: creatinine, glomerular filtration rate estimated by CKD-EPI, glucose, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, uric acid, C-reactive protein, fibrinogen, glycosylated hemoglobin. * Analytical parameter in urine: albumin/creatinine ratio in first morning urine. * Parameters in samples centralized in the Renal Pathophysiology Laboratory: array including more than 40 molecules that promote and inhibit inflammation and fibrosis; measurement of ACE and ACE2. * Cardiovascular events defined as one of the following: * Cardiovascular death. * Acute coronary syndrome. * Angina requiring hospitalization. * Coronary revascularization. * Transient ischemic attack or noncardioembolic ischemic stroke. * Peripheral vascular disease, defined as acute peripheral arterial embolism or ischemia, or need for amputation or percutaneous surgical revascularization. * Renal event, defined as one of the following: * 40% decrease in glomerular filtration rate estimated by CKD-EPI with respect to baseline. * Doubling of serum creatinine above baseline. * Persistent drop in glomerular filtration rate estimated by CKD-EPI below 15 mL/min/1.73m2. * Need for renal replacement therapy