A Study in Healthy Participants to Investigate Relative Bioavailability of AZD5004 in Three Solid Oral Formulations

Exclusion Criteria

• •History of any clinically important disease or disorder which, in the opinion of the Investigator, may either put the participant at risk because of participation in the study, or influence the results or the participant's ability to participate in the study
• •History of acute pancreatitis (unless due to previously resolved gallstone pancreatitis and post-cholecystectomy), chronic pancreatitis, gallstones, or elevation in serum lipase/pancreatic amylase.
• •Clinically significant inflammatory bowel disease, gastroparesis, severe disease, or surgery affecting the upper GI tract (including bariatric surgery).
• •Any clinically important illness, medical/surgical procedure, or trauma.
• •Any laboratory values with the deviations specified in protocol and clinically important abnormalities in clinical chemistry, hematology, or urinalysis results.
• •Any positive result at Screening for serum Hepatitis B surface antigen (HBsAg), Hepatitis B core antibody (HBcAb) or Human immunodeficiency Virus (HIV).
• •Abnormal vital signs, after 10 minutes supine rest, at Screening and/or admission to the Clinical Unit.
• •Serum triglyceride concentrations above 1000 mg/dL (11 mmol/L).
• •Basal calcitonin level \> 50 ng/L or pg/mL at Screening or history/family history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia (MEN), type 2.
• •Known or suspected history of alcohol or drug abuse or excessive intake of alcohol
• •Positive screen for drugs of abuse, or alcohol or cotinine (nicotine).
• •History of severe allergy/hypersensitivity or ongoing clinically important allergy/hypersensitivity or history of hypersensitivity to drugs with a similar chemical structure or class to AZD5004.
• •Excessive intake of caffeine-containing drinks or food
• •History of psychosis or bipolar disorder and major depressive disorder.
• •History of suicide attempt or history of suicidal ideation within the past year.