Age

55–80

Sex

ALL

Healthy volunteers

Not accepted

Primary diagnosis of depression (DSM-5 criteria, American Psychiatric Association 2013).
Depressive symptoms assessed using MADR, BDI, or ZDR scales.
Ability to provide written informed consent.
Self-reported moderate-intensity leisure physical activity of less than 150 minutes per week.

Patients with severe psychopathology.
Medical contraindications to physical activity.
Orthopedic problems or other conditions limiting physical fitness assessment or currently pregnant.
Patients who underwent antibiotic/anti-inflammatory treatments in the last 3 months
Active gastrointestinal diseases
Autoimmune and/or chronic inflammatory disorders

Implementation of a Multiple Intervention to Promote Healthy Lifestyles in Patients With Depression