Adequate completion of informed consent process with written documentation
Patients 18 - 65 years old
• Physician diagnosis of muco-obstructive pulmonary disease, including cystic fibrosis, severe asthma, chronic obstructive pulmonary disease, or non-cystic fibrosis bronchiectasis for \> 1 year
Able to perform reproducible spirometry according to ATS criteria based on clinical PFTs.
You may not be if
Respiratory tract infection within the 4 weeks prior to Visit 1
Body mass index (BMI) \> 30 at Visit 1
One-time doses such as intra-articular injections require a 4-week washout prior to Visit 1
ER visit related to pulmonary condition within the previous 4 weeks of Visit 1
Significant concomitant medical illness, including (but not limited to) heart disease, cancer, uncontrolled diabetes, other chronic lung diseases (determined by the Investigator.)
Resting O2 saturation \<90% with maximum supplemental O2 delivered by nasal canula
Positive urine pregnancy test
Participation in an intervention study (including bronchoscopy) or use of investigative drugs within the past 30 days or plans to enroll in such a trial during the study
Unable or unlikely to complete study assessments in the opinion of the Investigator
Study intervention poses undue risk to patient in the opinion of the Investigator
Conditions that will prohibit MRI scanning determined by the MRI safety screening.
