Pegylated Liposomal Doxorubicin (PLD) Versus Active Surveillance for Advanced Soft Tissue Sarcoma Patients Who Had Controlled Disease After Standard Anthracycline-based Treatment (MELODY)

Inclusion Criteria

• •1. A histologically confirmed advanced soft tissue sarcoma. Note that subtypes typically do not use chemotherapy as standard treatment are not allowed, such as alveolar soft part sarcoma, solitary fibrous tumor, extraskeletal myxoid chondrosarcoma, clear cell sarcoma)
• •2. Patients received first-line anthracycline-based treatment for a minimum of 4 cycles and a maximum of 8 cycles.
• •3. The best response after first-line anthracycline-based treatment must be either a complete response, partial response, or stable disease as defined by RECIST 1.1.
• •The best response should be attributed solely to systemic treatment and not to local therapy. All the patients must have at least one measurable tumor based on RECIST 1.1 before initiating first-line anthracycline-based treatment.
• •4. Patients must be randomized within 8 weeks of their last dose of anthracycline-based treatment
• •5. Patients have a life expectancy ≥ 3 months
• •6. Patients older than 18 years old.
• •7. ECOG performance status of 0 to 1.
• •8. Patients must have adequate organ function and marrow reserve measured within 7 days prior to randomization as defined below:
• •1. Hemoglobin ≥ 9.0 g/dL;
• •2. Absolute neutrophil count ≥ 1,500/mm3;
• •3. Platelets ≥ 100,000/mm3;
• •4. Total bilirubin ≤ 1.5 x upper normal limit;
• •5. AST(SGOT)/ALT(SGPT) ≤ 2.5 x upper normal limit; for patients with liver metastases AST(SGOT)/ALT(SGPT) ≤ 5 x upper normal limit is allowed;
• •6. Serum creatinine ≤ 1.5mg/dL or creatinine clearance ≥50ml/min;
• •7. All women of childbearing potential must have a negative pregnancy test obtained within 72 hours before starting therapy.
• •9. For male participants: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom, and agreement to refrain from donating sperm.
• •10. Patients with reproductive potential must use effective contraception (hormone orbarrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 6 months after the completion of therapy.
• •11. Patients must be able to comply with study procedures and sign informed consent.