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Genetic Markers of Diabetic Ulcers and Personalized Treatment Targets Research | Clinical Trials | Clareo Health

RECRUITING

Genetic Markers of Diabetic Ulcers and Personalized Treatment Targets Research

Clinical Investigation of Genetic Markers in Diabetic Ulcers and Their Role in Personalized Treatment Targeting

NCT06979037•The First Affiliated Hospital of University of South China

Summary

This clinical trial involves collecting peripheral blood, ulcer tissue, and fecal samples from diabetic ulcer patients for bioinformatics analysis to screen genetic markers significantly associated with ulcer risk and healing differences. Furthermore, multi-omics data will be integrated to establish a diabetic ulcer risk prediction model. Based on key single nucleotide polymorphisms and their regulatory pathways, potential new drug targets for promoting healing will be explored, providing a genetic basis for personalized treatment.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1\) Subjects who voluntarily participate in this clinical study and sign informed consent;
•2\) Patients with type 2 diabetes and diabetic ulcers;
•3\) Disease duration ≥ 10 years or age ≥ 55 years at enrollment;
•4\) Inpatient or outpatient who can be monitored by the same investigating team throughout the duration of the study.

Exclusion Criteria

•1\) Severe vascular occlusion or impairment;
•2\) Patients with congenital heart disease, aortic dissection, or other severe cardiovascular diseases;
•3\) Patients with ulcers caused by factors other than diabetes;
•4\) Patients with severe liver and kidney dysfunction or serious neurological impairment.

Locations (1)

The First Affiliated Hospital of University of South China

Hengyang, Hunan, China

Key Dates

Start Date

May 16, 2024

Primary Completion Date

May 16, 2027

Completion Date

May 16, 2027

Last Updated

May 18, 2025

Enrollment

712

ESTIMATED participants

Conditions

Diabetic Ulcers

Contacts

Jiecan Zhou, Prof.

CONTACT

+86-734-8279018 zhoujiecan@fsyy.usc.edu.cn

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 18, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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