A Trial of SHR7280 in Healthy Subjects

Exclusion Criteria

• •1. Individuals with a history of chronic or serious diseases, or current conditions affecting the respiratory, circulatory, digestive, urinary, hematological, endocrine, immune, nervous, or psychiatric systems, and deemed ineligible to participate in this trial by the investigator.
• •2. Females who are pregnant, breastfeeding, or with a positive serum pregnancy test during the screening or baseline period.
• •3. History of smoking (average daily cigarette consumption \>5 cigarettes) within 3 months prior to randomization, or any use of tobacco products during the study period.
• •4. History of drug abuse, positive urine drug abuse screen at the screening period.
• •5. Receipt of live (attenuated) vaccines within 1 month prior to screening or planned administration during the trial (excluding influenza vaccines).
• •6. Undergoing any surgical procedure within 3 months prior to randomization, incomplete recovery from surgery, or anticipated need for surgery or hospitalization during the trial period.
• •7. Inability to comply with standardized dietary requirements, intolerance to high-fat meals, or presence of dysphagia.
• •8. Any condition judged by the investigator to potentially affect drug absorption, distribution, metabolism, or excretion, reduce compliance, or pose other risks that make participation in the study inappropriate.