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The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery | Clinical Trials | Clareo Health

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The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery

Analysis of the Relationship Between the Concentration of the Brain Derived Neurotrophic Factor (BDNF) in Plasma, the Occurrence of BDNF Gene Polymorphism (Val66Met) and White Blood Cell Markers and the Incidence of Postoperative Central Nervous System Disorders in Patients Undergoing General Anesthesia for Cardiac Surgery With Extracorporeal Circulation

NCT06967779•Pomeranian Medical University Szczecin

View on ClinicalTrials.gov

Summary

This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury induced by cardio-pulmonary by-pass and its association with genetic predisposition in patients undergoing coronary artery bypass grafting (CABG) carrying BDNF gene polymorphism (Val66Met).

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Age \> 18 years.
•2. Planned coronary artery bypass grafting (CABG) procedure with the use of cardiopulmonary by-pass (CPB).
•3. Ability to understand and sign an informed consent form.

Exclusion Criteria

•1. Emergency surgery.
•2. Previous known cognitive disorders: Mini Mental State Examination (MMSE) score \<15.
•3. Baseline delirium (positive CAM test prior to surgery).
•4. Diagnosis of psychiatric syndromes in the past - i.e. depression, dementia, psychosis or schizophrenia.
•5. Inability to understand Polish language.
•6. Inability to give and sign informed consent due to auditory or visual dysfunction.

Locations (1)

Uniwersytecki Szpital Kliniczny nr 2 PUM w Szczecinie

Szczecin, West Pomeranian Voivodeship, Poland

Key Dates

Start Date

July 1, 2021

Primary Completion Date

July 1, 2023

Completion Date

July 1, 2024

Last Updated

May 15, 2025

Enrollment

107

ACTUAL participants

Conditions

Delirium - PostoperativeBDNFCABG

The Association Between Postoperative Inflammatory and Neurological Serum Biomarker Concentrations and Occurrence of Postoperative Delirium

NCT07411612

Delirium - PostoperativeNeuronal Damage+3 more

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RECRUITINGNA

Multimodal VR Rehabilitation for Cardiorespiratory Fitness in CABG Phase II

NCT07331558

CABG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 15, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery

Inclusion Criteria

Exclusion Criteria

The Association Between Postoperative Inflammatory and Neurological Serum Biomarker Concentrations and Occurrence of Postoperative Delirium

Multimodal VR Rehabilitation for Cardiorespiratory Fitness in CABG Phase II

Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture Surgery

Utility of the Superior Vena Cava Collapsibility Index (SVC-CI) to Predict Fluid Responsiveness in Patients With Coronary Artery Disease Undergoing Surgical Revascularization

Effect of Transcranial Direct Current Stimulation on Postoperative Delirium in Elderly Patients

Effect of Nurse-Led Education and Tele-Interventions on Reducing Surgical Site Infections in Patients After Coronary Artery Bypass Surgery: a Clinical Trial