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We will test the hypothesis that increasing skin wetness, and thus evaporative cooling, will attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. Secondly, we propose that wearing a water-saturated T-shirt will also be beneficial to attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. To accomplish these objectives, individuals with congestive heart failure and otherwise healthy control individuals will be exposed to the simulated heat wave condition (hot and dry) with the following cooling modalities: A) control trial (no limb immersion or skin wetting), B) skin wetting only trial, and C) water-saturated T-shirt trial in a randomized crossover fashion. Thermoregulatory and cardiovascular responses will be evaluated throughout these simulated heat wave exposures. Primary outcomes variables will be skin and core temperatures, while secondary variables will include measures of cardiovascular stress, myocardial perfusion, heart rate, and echo-based measures of cardiac function.
Age
45 - No limit years
Sex
ALL
Healthy Volunteers
Yes
Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States
Start Date
October 1, 2025
Primary Completion Date
July 1, 2030
Completion Date
July 1, 2030
Last Updated
March 9, 2026
88
ESTIMATED participants
Control Trial
OTHER
Water-saturated T-shirt trial
OTHER
Skin-Wetting Trial
OTHER
Lead Sponsor
University of Texas Southwestern Medical Center
NCT07484009
NCT07191730
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