Meet the diagnostic criteria for migraine in the International Classification of Headache (ICHD-3);
Confirmation of patent foramen ovale through transthoracic echocardiography(TTE) or transesophageal echocardiography(TEE)/right heart contrast echocardiography
Agree to participate in the study and sign the informed consent form.
You may not be if
Can not sign the informed consent form or cooperate with follow-up.
