Biomarkers in Patients With Anemia-Induced Thrombocytopenic Bleeding

Exclusion Criteria

• •1. Failure to provide informed consent.
• •2. Unwilling to receive blood transfusions.
• •3. Life expectancy \<72 hours.
• •4. Undergoing palliative chemotherapy.
• •5. Requires specialized blood products (e.g., antigen-matched, irradiation, etc.).
• •6. Diagnosis of acute promyelocytic leukemia.
• •7. Diagnosis of hyperleukocytosis (a white blood cell count exceeding 100 × 10\^9/L).
• •8. Diagnosed with coagulopathies or ongoing treatment with therapeutic anticoagulants, aspirin or nonsteroidal anti-inflammatory drugs (history of inherited or acquired coagulation disorder, known hemolytic disease, INR \> 1.5)
• •9. Evidence of iron overload (ferritin \>800 ng/mL, transferrin saturation \>80%) .