Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Sara Poletti
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
A depressive episode according to Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria in the course of MDD or BD with:
* HDRS score \> 17
* Age 18-65 years;
Signed informed consent, able to understand, speak and write the national language
Having a positive nasopharyngeal swab for COVID-19 in the last 36 months;
Age between 18-25 years;
Signed informed consent, able to understand, speak and write the national language
You may not be if
History of schizophrenia, schizoaffective disorder, psychosis not otherwise specified; anorexia or bulimia nervosa;
Taking following medications: antipsychotics, anticonvulsants, mood stabilizers; stimulants
Active infection requiring antibiotics therapy;
Immunosuppressed patient or other chronic diseases
Signs of active infection requiring treatment
Use of anti-inflammatory medication on a regular basis for a chronic inflammatory/autoimmune Disorder. Forbidden treatment: corticosteroids, Non Steroidal Anti-inflammatory Drugs, immunosuppressant IV-Ig based treatment
Ongoing fever, infection treated by antibiotics or uncontrolled diabetes type I or II;
Existing cancer or history of cancer in the last 5 years (except skin epidermoid cancer or in-situ cervix cancer);
Known HIV infection or clinically manifest Acquired Immune Deficiency Syndrome (AIDS), Parkinson's or Alzheimer's disease, or any other serious condition likely to interfere e with the conduct of the trial;
Abuse of drugs or alcohol in the past 6 months
Comorbidity for psychotic disorders, verified by SCID-CV;
Current and clinically significant substance use disorder;
Current comorbidity with neurological conditions or severe head trauma, general brain disorder preceding the emergence of PASC, including microhaemorrhages and/or ischaemia occurring during the acute phase of COVID;
Neuropsychological diagnosis of intellectual disability;
Presence of contraindications to blood sampling and/or MRI;
Pregnancy status at the time of recruitment.
Aneurysm clip
Implanted neural stimulator
Implanted cardiac pacemaker or auto-defibrillator
Cochlear implant
Ocular foreign body (e.g., metal shavings)
Any implanted device (pumps, infusion devices, etc)
Shrapnel injuries.
For epidemiological cohorts (MoBa, TOP, CHS) age between 18 and 65 ya, diagnosis of a severe mental illness (Schizophrenia, Major Depression, Bipolar disorder, anxiety disorders),
Clareo Health | Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections
