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Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections: Translating Epidemiology to Deep-phenotyping
This observational study aims to identify the underlying neurobiological and environmental mechanisms that influence vulnerability or resilience to mental illness in the context of infection and their contribution to severe infective outcomes in people with pre-existing mental illness. The main questions it aims to answer are: * How do viral infections influence the development of mental illness? * What neurobiological and environmental factors contribute to influence the development of mental illness following infection? * How do these factors relate to the severity of infectious illness in people with pre-existing mental disorders? Researchers will move from large population databases to well-defined, deeply characterised samples to explore the association between infection and subsequent mental health outcomes, and the biological mechanisms behind these changes. Participants's data has already been collected.
Age
18 - 65 years
Sex
ALL
Healthy Volunteers
No
University of Antwerp
Antwerp, Belgium, Belgium
University of Haifa
Haifa, Israel, Israel
IRCCS Ospedale San Raffaele
Milan, Italy, Italy
University of Oslo
Oslo, Norway, Norway
Start Date
May 2, 2024
Primary Completion Date
May 1, 2026
Completion Date
March 1, 2027
Last Updated
May 14, 2025
408,551
ACTUAL participants
This research doesn't involve any kind of intervention on the study participants
OTHER
Lead Sponsor
Sara Poletti
NCT00397280
NCT06200207
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT04638647