Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections

Exclusion Criteria

• •History of schizophrenia, schizoaffective disorder, psychosis not otherwise specified; anorexia or bulimia nervosa;
• •Taking following medications: antipsychotics, anticonvulsants, mood stabilizers; stimulants
• •Active infection requiring antibiotics therapy;
• •Immunosuppressed patient or other chronic diseases
• •Signs of active infection requiring treatment
• •Use of anti-inflammatory medication on a regular basis for a chronic inflammatory/autoimmune Disorder. Forbidden treatment: corticosteroids, Non Steroidal Anti-inflammatory Drugs, immunosuppressant IV-Ig based treatment
• •Ongoing fever, infection treated by antibiotics or uncontrolled diabetes type I or II;
• •Existing cancer or history of cancer in the last 5 years (except skin epidermoid cancer or in-situ cervix cancer);
• •Known HIV infection or clinically manifest Acquired Immune Deficiency Syndrome (AIDS), Parkinson's or Alzheimer's disease, or any other serious condition likely to interfere e with the conduct of the trial;
• •Abuse of drugs or alcohol in the past 6 months
• •Comorbidity for psychotic disorders, verified by SCID-CV;
• •Current and clinically significant substance use disorder;
• •Current comorbidity with neurological conditions or severe head trauma, general brain disorder preceding the emergence of PASC, including microhaemorrhages and/or ischaemia occurring during the acute phase of COVID;
• •Neuropsychological diagnosis of intellectual disability;
• •Presence of contraindications to blood sampling and/or MRI;
• •Pregnancy status at the time of recruitment.
• •Aneurysm clip
• •Implanted neural stimulator
• •Implanted cardiac pacemaker or auto-defibrillator
• •Cochlear implant
• •Ocular foreign body (e.g., metal shavings)
• •Any implanted device (pumps, infusion devices, etc)
• •Shrapnel injuries.
• •For epidemiological cohorts (MoBa, TOP, CHS) age between 18 and 65 ya, diagnosis of a severe mental illness (Schizophrenia, Major Depression, Bipolar disorder, anxiety disorders),