Cryoneurolysis in Patients Awaiting Total Hip and Knee Arthroplasty

Exclusion Criteria

• •If surgery is expected to be completed within 1 month of the intervention as this would limit our ability to evaluate the effectiveness of the cryoneurolysis procedure
• •Allergies to local anesthetics
• •Inability to communicate with investigators
• •Opioid use disorder
• •History of severe psychiatric or medical conditions which hinder effective communication
• •Living more than 1 hour away from the hospital where the study is taking place or unable to travel to the hospital for the interventions and follow up
• •Body mass Index (BMI) ≥40
• •Any contraindications specific to percutaneous cryoneurolysis such as history of bleeding diathesis, any active infections at the procedural site, cold urticaria, cryofibrinogenemia, cryoglobulinemia, paroxysmal cold hemoglobinuria, or Raynaud's disease (see Ilfeld \& Finneran, 2020)
• •Use of therapeutic anticoagulation
• •Diagnosis of Non-Osteoarthritis as the cause for THA or TKA
• •Other chronic pain condition which patients may be taking opioids to control the pain (e.g. Fibromyalgia or Complex Regional Pain Syndrome)
• •Less than 50% reduction in pain with diagnostic blocks using 0.5% bupivacaine