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Feasibility of Tracheobronchial Defect Reconstruction Using Allogenic Aortic Patch | Clinical Trials | Clareo Health

RECRUITINGNA

Feasibility of Tracheobronchial Defect Reconstruction Using Allogenic Aortic Patch

NCT06935110•National Taiwan University Hospital

Summary

The investigators investigate the feasibility and safety of using cryopreserved aortic patches for tracheal or bronchial defect repair.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Congenital tracheal deformities: Includes congenital tracheomalacia, congenital tracheobronchial malformations, complete tracheal rings, etc., with severe clinical symptoms and cases where treatment is recommended after evaluation.
•2. Acquired tracheal stenosis: Includes tracheal narrowing caused by diseases, endotracheal intubation, or postoperative scar tissue, with severe clinical symptoms and cases where treatment is recommended after evaluation.
•3. Tracheal injury or tissue defect caused by trauma or burns: Cases requiring surgical repair.
•4. Tracheal tumors: Reconstruction of tracheal tissue following the removal of benign or malignant tumors.

Exclusion Criteria

•1. Patients who are unable to provide informed consent.
•2. Pulmonary tumors that can be treated with standard lobectomy.
•3. Locally invasive tumors that are unresectable.
•4. Presence of contralateral lymph node metastasis.
•5. Presence of distant metastasis, except for solitary, resectable brain metastasis.
•6. Tracheal lesions amenable to standard resection with direct anastomosis.
•7. Preoperative evaluation indicates inability to undergo standard lobectomy.
•8. Patients infected with human immunodeficiency virus (HIV) or with other immunodeficiency disorders.
•9. Any condition or circumstance deemed by the principal investigator to potentially interfere with the conduct of the trial (e.g., severely impaired cardiopulmonary function, significant liver or kidney dysfunction, poorly controlled diabetes, high-risk groups, or pregnancy).
•10. Individuals with concerns about the potential risks of the trial.

Locations (2)

National Taiwan University Hospital

Taipei, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Key Dates

Start Date

September 15, 2025

Primary Completion Date

July 31, 2029

Completion Date

October 1, 2029

Last Updated

December 3, 2025

Enrollment

ESTIMATED participants

Conditions

Trachea DiseasesAirway RemodelingReconstruction Surgery

Interventions

Cryopreserved aortic patch

PROCEDURE

Contacts

Chao-Wen Lu, MD

CONTACT

+886972652324 i2363160@gmail.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 3, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.