Effects of Endogenous GIP on Postprandial Blood Pressure in Healthy Individuals

Exclusion Criteria

• •1. Allergy or intolerance to ingredients included in the mixed meal
• •2. History of Orthostatic Hypotension (OH) or Postural Orthostatic Tachycardia Syndrome (POTS) or other autonomic dysfunction at the discretion of the investigators
• •3. Anaemia (haemoglobin below normal range \<7.3 mmol/L for women and \<8.3 mmol/L for men)
• •4. Kidney disease (estimated glomerular filtration rate (eGFR) \<90 ml/min/1.73 m2) at screening
• •5. Known liver disease and/or elevated plasma alanine aminotransferase (ALT) \> three times the upper limit of normal at screening
• •6. Treatment with antihypertensives
• •7. Treatment with GLP-1RA (Glucagon-like Peptide-1 Receptor Agonist)
• •8. Treatment with SNRI (Serotonin and Noradrenalin Reuptake Inhibitor) or treatment within two weeks before the first experimental day
• •9. Any ongoing medication that the investigator evaluates would interfere with trial participation
• •10. Any physical or psychological condition that the investigator evaluates would interfere with trial participation, including any acute or chronic illnesses
• •11. Any concomitant disease or treatment that, at the discretion of the investigators, might jeopardize the participant's safety during the trial
• •12. Alcohol/drug abuse as per discretion of the investigators
• •13. Pregnancy or breastfeeding
• •14. Participation in any other clinical trial during the study period
• •15. Mental incapacity or language barriers that preclude adequate understanding or cooperation or unwillingness to comply with trial requirements or pr discretion of the investigator