Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck Cancer

Exclusion Criteria

• •Severe hearing impairment (WHO grade 3 or 4, corresponding to an audiometric ISO value of ≥61 dB in the better ear at frequencies of 500, 1000, 2000 and 4000 Hz)
• •Self-reported tinnitus or vestibular dysfunction in the last 3 months (only lead to exclusion of the corresponding secondary objectives, not to complete exclusion from the study)
• •Current cochlear implant
• •Concurrent treatment with loop diuretics (e.g. furosemide), aminoglycoside antibiotics or other known ototoxic substances in the last three months
• •Acute psychosis or serious psychiatric illness
• •Addiction disorder