R-MVST Cells for Treatment of Viral Infections in Children and Young Adults

Exclusion Criteria

• •Patients with other uncontrolled infections, except for CMV, EBV, ADV or BK. For bacterial infections, patients must be receiving definitive therapy and have no signs of progressing infection for 72 hours prior to the day of infusion. For fungal infections, patients must be receiving definitive systemic anti-fungal therapy and have no signs of progressing infection for 1 week prior to R-MVST infusion. Progressing infection is defined as hemodynamic instability attributable to sepsis or new symptoms, worsening physical signs or radiographic findings attributable to infection. Persisting fever without other signs or symptoms will not be interpreted as progressing infection.
• •Patients who receive corticosteroids at ≥ 0.5mg/kg prednisone or equivalent.
• •Patients who received anti-thymocyte globulin (ATG, Alemtuzumab (Campath), or other T-Cell immunosuppressive monoclonal antibodies in the last 28 days.
• •Patients who received methotrexate, or other antimetabolite-type immunosuppressants that are toxic to proliferating T cells in the last 7 days.
• •Patients who received extracorporeal photopheresis within the last 28 days.
• •Patients who received checkpoint inhibitor agents (e.g., nivolumab, pembrolizumab, ipilimumab) within 3 drug half-lives of the most recent dose to the infusion of R-MVST.
• •Received donor lymphocyte infusion in last 28 days.
• •Evidence of GVHD ≥ grade 2
• •Evidence of biopsy-proven acute rejection in SOT recipients
• •Active and uncontrolled relapse of malignancy
• •Patients who are pregnant, or breastfeeding.
• •Female of childbearing potential, or male with a female partner of childbearing potential, unwilling to use a highly effective method of contraception.
• •Uncontrolled intercurrent illness including, but not limited to symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• •Patients who have received investigational (IND) product within 14 days of infusion of the the R-MVST cells.
• •Unable or unwilling to receive infusions at Morgan Stanley Children's Hospital.