Efficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease

Inclusion Criteria

• •Age · Patients 18 years of age or older
• •Ocular Health
• •* Chronic corneal epithelial disease with fluorescein staining score 6 by NEI grading scale or persistent corneal epithelial defect present for longer than 14 days despite standard treatment
• •* No objective clinical evidence of significant (\> 50%) improvement/worsening of the epithelial disease in the last 14 days
• •* Epithelial disease refractory to conventional non-surgical treatments (e.g., preservative-free artificial tears, gels or ointments; discontinuation of preserved topical drops; anti-inflammatory therapy)
• •Study Procedures
• •* Only patients who satisfy all Informed Consent requirements may be included in the study. The patient and/or his/her legal representative must read, sign and date the Informed Consent document before any study-related procedures are performed. The Informed Consent form signed by patients and/or legal representative must have been approved by the UIC IRB for the current study. Patients must have the ability and willingness to comply with study procedures.