Surgical vs Endoscopic Treatments as ImmunoModulating Interventions in High-Risk Acute Calculous Cholecystitis

Inclusion Criteria

• •have a diagnosis of ACC as defined by 2018 Tokyo Guidelines criteria
• •be ≥ 18 years old
• •have a POSSUM PS ≥ 25
• •onset of symptoms \<= 7 days before Emergency Department (ED) admission
• •provide signed and dated informed consent form
• •willing to comply with all study procedures and be available for the duration of the study
• •have an Israelian Score (IS) (Table 3) for the risk of main bile duct stones \<2 or an IS =2 and an EUS or a MRCP negative for main bile duct stones