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Oxygenation Procedure for Obese Patients Using High Flow Oxygen Therapy Combined With Non-invasive Ventilation During Intubation in the Operating Room: a Randomised Controlled Trial
Obesity is a risk factor for difficult intubation, with an incidence of up to 15.5%, and difficult mask ventilation. Obesity also reduces the functional residual capacity (FRC) of the lungs, the main reservoir of oxygen during apnoea. Complications associated with induction and intubation in the operating room are more frequent in obese patients. Preoxygenation is a cornerstone in the management of patients at risk of desaturation during induction. The study aims to compare two oxygenation strategies , in obese patients. Oxygenation using a combination of NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen) compared with NIV alone in the operating room for induction of general anaesthesia with orotracheal intubation.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
CHU Clermont Ferrand - Site Estaing
Clermont-Ferrand, France
Clinique Honoré Cave
Montauban, France
Hôpital Saint Eloi - CHU Montpellier
Montpellier, France
Clinique Mutualiste La Sagesse
Rennes, France
Clinique Pasteur
Toulouse, France
Start Date
June 19, 2025
Primary Completion Date
March 1, 2027
Completion Date
March 1, 2027
Last Updated
March 6, 2026
124
ESTIMATED participants
NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen)
PROCEDURE
NIV (Non Invasive Ventilation)
PROCEDURE
Lead Sponsor
Clinique Pasteur
NCT06639737
NCT06666686
Data Source & Attribution
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