Tissue Microdialysis Monitoring of Liver Grafts

Clinical Applicability of Tissue Microdialysis for Early Assessment of Liver Graft Metabolism in Patients After Orthotopic Liver Transplantation

NCT06890234•University Medical Centre Ljubljana

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Summary

This study will investigate the dynamics of metabolic molecules sampled from human liver grafts during the early postoperative period using tissue microdialysis. The obtained tissue samples will be compared with standard liver function tests and dynamic functional liver assessment tests. The primary objective is to evaluate the clinical feasibility, utility, and non-inferiority of tissue microdialysis in comparison to current standard methods for monitoring liver grafts.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Adult patients aged between 18 and 65 years.
•Liver transplant candidates on the Slovenian liver transplant waiting list, matched with an available liver graft through the Eurotransplant system, and scheduled for the surgical procedure.
•Signed informed consent to participate in the microdialysis sampling research project, including consent to share the obtained samples with other research studies

Exclusion Criteria

•Patients under 18 or over 65 years of age.
•Refusal to participate in the study.
•Verbal withdrawal of consent at any point during the study, even if informed consent has been previously signed.
•Surgical contraindications preventing the insertion of a microdialysis catheter into the liver graft during the procedure.
•Surgical revision within 48 hours post-transplantation resulting in liver graft loss and removal.
•History of allergic reactions to radiographic contrast media.
•Death during the liver transplant procedure.

Locations (1)

University Medical Centre Ljubljana

Ljubljana, Slovenia, Slovenia

Key Dates

Start Date

May 11, 2022

Primary Completion Date

August 1, 2025

Completion Date

December 31, 2025

Last Updated

March 21, 2025

Enrollment

ESTIMATED participants

Conditions

Liver TransplantationLiver Graft DysfunctionTissue Metabolism

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 21, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Tissue Microdialysis Monitoring of Liver Grafts

Inclusion Criteria

Exclusion Criteria

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