Non-Surgical Laser Treatment for Peri-Implantitis: Er:YAG & Diode Laser

This study aims to compare the effectiveness of non-surgical peri-implantitis treatment using conventional ultrasonic debridement versus a laser-assisted approach. The primary objective is to assess clinical, microbiological, and metabolomic outcomes associated with each treatment modality. The study will be conducted at the Postgraduate Periodontology Clinic of the School of Dentistry, Aristotle University of Thessaloniki. Participants will be screened based on inclusion and exclusion criteria, and those diagnosed with peri-implantitis in at least one implant will be randomly assigned to either the control or experimental group. Study Procedures: Control Group: Treatment with ultrasonic scalers designed for implants and saline irrigation. Experimental Group: Treatment with Er:YAG (2940nm) and Diode (808nm) laser. Oral Hygiene Instructions: Provided at baseline and each follow-up visit. Microbiological Sampling: Collection of subgingival plaque using sterile paper cones before and after treatment (3 months), with analysis of P. gingivalis and F. alocis using qPCR. Metabolomic Analysis: Collection of peri-implant crevicular fluid before and after treatment for metabolomic profiling. Clinical Parameters: PPD, BOP, CAL, REC, and SUP will be recorded at baseline and after 3 months. Pain and Patient Satisfaction: VAS pain assessment at multiple time points and tracking of analgesic consumption. A patient satisfaction questionnaire will be completed at the end of the study. Study Outcomes: Primary Outcome: Reduction in peri-implant pocket depth and inflammation. Secondary Outcomes: Changes in microbiological and metabolomic markers, pain perception, and patient-reported satisfaction. This randomized controlled clinical trial aims to provide valuable insights into the efficacy of laser-assisted non-surgical therapy for peri-implantitis compared to conventional ultrasonic debridement. The findings could contribute to the optimization of non-surgical treatment protocols for peri-implant disease management.