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A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries | Clinical Trials | Clareo Health

COMPLETEDPHASE4

A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries

A Phase 4, Open-label, Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine As Part of Multimodal Therapy for Acute Pain After Laparoscopic Procedures of the Intraperitoneal or Retroperitoneal Cavities or Arthroscopic Orthopedic Procedures

NCT06887959•Vertex Pharmaceuticals Incorporated

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Body mass index (BMI) of greater than or equal to (≥) 18.0 to less than or equal to (≤) 40.0 kilogram per meter square (kg/m\^2)
•Scheduled to undergo a procedure that is in one of the following categories that would typically be treated with opioid therapy for at least 72 hours postoperatively such as
•* Laparoscopic intraperitoneal or retroperitoneal procedure
•* Arthroscopic orthopedic procedure

Exclusion Criteria

•Participated in previous study with Suzetrigine or received Journavx

Locations (17)

Scottsdale Clinical Trials

Scottsdale, Arizona, United States

Woodland International Research Group

Little Rock, Arkansas, United States

Gulfcoast Research Institute

Sarasota, Florida, United States

MedStar

Baltimore, Maryland, United States

Oasis Clinical Research

Las Vegas, Nevada, United States

Cooper University HealthCare (CUH)

Camden, New Jersey, United States

North Shore University Hospital - Anesthesiology

Manhasset, New York, United States

OrthoCarolina - Hip & Knee Center

Charlotte, North Carolina, United States

Eximia Research-Durham

Durham, North Carolina, United States

Duke University Hospital - Anesthesiology

Durham, North Carolina, United States

Key Dates

Start Date

March 27, 2025

Primary Completion Date

October 27, 2025

Completion Date

November 10, 2025

Last Updated

December 15, 2025

Enrollment

ACTUAL participants

Conditions

Acute Pain

Interventions

Suzetrigine

DRUG

Acute Effects of LLLT on Pain Threshold and Pain Tolerance

NCT07422272

Pain ThresholdPain Tolerance+3 more

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RECRUITINGNA

Clinical Utility of the Numerical Verbal Scale (NVS) and the Pain and Functional Activity Scale (PFAS) in the Management of Rescue Analgesia in Acute Postoperative Pain. Randomized Study.

NCT07310953

AnalgesiaPost Operative Pain+2 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 15, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries

Inclusion Criteria

Exclusion Criteria

Acute Effects of LLLT on Pain Threshold and Pain Tolerance

Clinical Utility of the Numerical Verbal Scale (NVS) and the Pain and Functional Activity Scale (PFAS) in the Management of Rescue Analgesia in Acute Postoperative Pain. Randomized Study.

Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises

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ESKetamine Low-dose vs Ketamine Low-dose for Severe Acute Pain in Emergency Units, Comparison of PsychodyslEptic Effects