Histopathological diagnosis of colorectal cancer stage I or II according to the TNM (Tumor, Node, Metastasis) classification
Patients with tumors classified as T1-T3, N0, M0 (stage I-II) eligible for surgery
Ability to understand and sign the informed consent
Clinically stable patients with no significant changes in renal function or disease management in the weeks prior to enrollment \*\*
For the non-CKD group
Adequate liver, renal and bone marrow function (adequate levels of hemoglobin, platelets, creatinine and bilirubin)
For the CKD group
Confirmed diagnosis of chronic kidney disease according to the KDIGO (Kidney Disease: Improving Global Outcomes) guidelines defined by a duration of at least three months with structural or functional abnormalities of the kidneys
BSA (Body Surface Area Area) eGFR≤60 ml/min/1.73 m2
You may not be if
Recent episodes of acute renal failure
Kidney transplant, autoimmune diseases; inflammatory bowel diseases; other than oncological or oncohematological diseases of CRC
Recent therapies with steroids/immunosuppressants and cardiovascular events (within 3 months of enrollment)
History of serious allergic reactions to iodinated contrast agents or gadolinium-based contrast agents
Recent or planned invasive or surgical treatments that could interfere with the study (within 3 months of enrollment)
Psychiatric disorders that could impair the patient's ability to follow study procedures or provide informed consent
Other types of concomitant or previous tumors in the previous 5 years of enrollment
Pregnant or breastfeeding women. Pregnancy status will be ascertained before enrollment by measuring Beta-hCG in urine (Pregnancy Test or urinary beta-HCG) or in blood (plasma beta-hCG).
