An Innovative Method in SAliva Samples for the Early Differential Diagnosis of High-impact NeuroDegenerative Diseases Through Raman Spectroscopy

Inclusion Criteria

• •FOR ALL SUBJECTS: between 60 and 85 years old
• •FOR CASE:
• •1. ADD: diagnosis of dementia due to AD according to clinical criteria and supported by amyloid biomarkers (biomarkers in CSF or brain PET scan with amyloid-specific tracer) according to the definition biological or neurochemical definition of disease.
• •2. FTD: diagnosis of FTD-bv (behavioral variant) according to current clinical criteria.
• •3. PD: diagnosis according to MDS criteria; stable drug treatment (last 4 weeks).
• •4. APs: clinical diagnosis of Progressive Supranuclear Palsy according to the criteria of Hoglinger 2017, Corticobasal Degeneration according to the criteria of Armostrong 2013, Multisystem Atrophy according to the criteria of Wenning 2022.
• •5. ALS: clinical diagnosis according to the criteria of Brooks (2000) and subsequent revisions.
• •FOR CONTROL SUBJECTS
• •1. subjects admitted to IRCCS Don Gnocchi Florence in the departments of cardiology, pulmonology, orthopedics
• •2. ABSENCE of neurological symptoms
• •3. ABSENCE OF diagnosis of neurological or psychiatric diseases.
• •4. absence of positive family history (relatives I and II degree) for NDDs.
• •5. condition of clinical stability
• •6. at least 15 days after the acute event causing hospitalization.
• •FOR PRODROMAL CASE
• •1. Prodromal PD according to Berg's criteria.
• •2. prodromal FTD-bv according to Barker's criteria
• •3. prodromal AD according to the criteria of Dubois and Albert