Finding studies
Finding studies
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Joana B. Pereira, PhD
CONTACT
Lead
Karolinska Institutet
With
To achieve this aim, the investigators will perform six different studies that have been designed to achieve the following specific objectives: 1.1. Identify changes of brain connectivity in individuals who show abnormal AD amyloid biomarkers in the cerebrospinal fluid and blood. 1.2. To assess the correlation between brain connectivity changes and biomarkers of synaptic dysfunction and inflammation as well as alterations of electrical brain signals. 1.3. Establish whether alterations of brain connectivity could be improved after patients start treatment with cholinesterase inhibitors. 1.4. Assess differences in brain connectivity between patients receiving treatment with statins and those not taking this medication. 1.5. Determine whether brain connectivity changes can predict longitudinal cognitive decline and conversion to AD dementia. 1.6. Assess whether different microorganisms can grow more rapidly in the cerebrospinal fluid from AD patients compared to controls and whether their levels are associated with brain connectivity. 1.7. Evaluate the relationship between brain connectivity and the integrity of the locus coeruleus, which is the earliest site of AD pathology
Age
40–85
Sex
ALL
Healthy volunteers
Accepted