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An Open-Label Phase 1 Study to Evaluate PF-08046032 as Monotherapy and Part of Combination Therapy in Participants With Advanced Malignancies
The purpose of this study is to learn about the effects of a new study medicine called PF-08046032, when taken alone and when taken with another medicine called sasanlimab, for the treatment of advanced cancers. The effects are studied in adult participants with certain types of lymphomas or solid tumors that are advanced or metastatic (spread to other parts of the body). The study has three parts: * Part A will test PF-08046032 alone at increasing dose levels in participants with certain lymphomas (cancer that begins in cells of the immune system) and in participants with certain solid tumors whose disease has worsened on or after standard treatments. * Part B will test PF-08046032 (at selected doses) and sasanlimab in participants with certain solid tumors, including those whose disease has worsened on or after standard treatments as well as participants before receiving standard treatments. * Part C will further test the combination of PF-08046032 and sasanlimab in participants with specific types of solid tumors based on the results from Part A and Part B of the study. All participants will receive the study drug PF-08046032. Only participants in Part B and Part C of the study will also receive sasanlimab. PF-08046032 will be given as an intravenous (IV) infusion, which means it will be injected directly into a vein. Sasanlimab will be given as a subcutaneous injection, which means it will be injected under the skin.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
NEXT Oncology
San Antonio, Texas, United States
Fred Hutchinson Cancer Center.
Seattle, Washington, United States
University of Washington Medical Center- Montlake
Seattle, Washington, United States
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain
Start Date
May 8, 2025
Primary Completion Date
February 27, 2026
Completion Date
February 27, 2026
Last Updated
February 19, 2026
6
ESTIMATED participants
PF-08046032
DRUG
Sasanlimab
DRUG
Lead Sponsor
Pfizer
NCT05139017
NCT01804686
Data Source & Attribution
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Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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