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Evaluating Therapeutic Electrical Stimulation to Improve Nerve Healing After Surgical Repair of Digital Nerve Injuries | Clinical Trials | Clareo Health

RECRUITINGNA

Evaluating Therapeutic Electrical Stimulation to Improve Nerve Healing After Surgical Repair of Digital Nerve Injuries

Function And Speed of Transection Recovery After Therapeutic Electrostimulation of Nerves

NCT06867185•Checkpoint Surgical Inc.

View on ClinicalTrials.gov

Summary

The goal of this clinical study is to evaluate if a period of electrical stimulation delivered during the surgical repair procedure can speed up nerve healing.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age 18-80 years
•Candidate for surgical intervention under general anesthesia.
•Require primary nerve injury repair in at least 1 digital nerve.
•Following resection, have a resulting nerve gap of ≤ 10mm.
•Able to complete tension-free end-to-end direct repair, or repair with a conduit, autograft, or allograft with a length ≤15mm
•Signed and dated informed consent form.

Exclusion Criteria

•Severe comorbid conditions, such as arrhythmia or congestive heart failure, preventing surgery under general anesthesia.
•Nerve repair occurring \>1 month post-injury.
•Incomplete nerve transection.
•Injury requiring replantation of target digit
•Injury distal to the distal interphalangeal joint.
•Injury proximal to branching into the proper or common digital nerves.
•Injuries to both digital arteries of an affected digit.
•History of neuropathy, diabetic neuropathy, or any other known neuropathy
•History of chronic ischemic condition of the upper extremity
•Cognitive impairment preventing the ability to provide consent, follow post-operative instructions, or complete clinical assessments.

Locations (5)

Indiana Hand to Shoulder Center

Indianapolis, Indiana, United States

University of Missouri Department of Orthopaedic Surgery

Columbia, Missouri, United States

Washington University in St Louis, Department of Orthopedic Surgery

St Louis, Missouri, United States

The Ohio State Univeristy - Department of Plastic and Reconstructive Surgery

Columbus, Ohio, United States

Harborview Medical Center - University of Washington

Seattle, Washington, United States

Key Dates

Start Date

April 24, 2025

Primary Completion Date

January 1, 2027

Completion Date

March 1, 2027

Last Updated

January 9, 2026

Enrollment

ESTIMATED participants

Conditions

Digital Nerve InjuryNerve InjuryNerve ReconstructionNerve TraumaDigital Nerve Lesion

Interventions

Brief Electrical Stimulation Therapy

DEVICE

Digital Nerve Repair

PROCEDURE

Contacts

Director of Clincal Reseach

CONTACT

877-478-9106 clinical@checkpointsurgical.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 9, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Evaluating Therapeutic Electrical Stimulation to Improve Nerve Healing After Surgical Repair of Digital Nerve Injuries

Inclusion Criteria

Exclusion Criteria

Regeneration of Acutely Injured Nerves With Temporary Electrical Stimulation

Cast Or ePineural Suture for Digital Nerve Injuries - a Randomised Controlled Study

Nerve Repair Using Hydrophilic Polymers to Promote Immediate Fusion of Severed Axons and Swift Return of Function

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

Comparison of the Results of Biostimulation Treatment of Inferior Alveolar Nerve Injury Using Nd:YAG and Diode Lasers With Different Wavelengths.

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