A Study of LCAR-AIO in Subjects With Relapsed/Refractory Autoimmune Diseases

Inclusion Criteria

• •1. Subjects voluntarily participate in clinical research.
• •2. Age 18-65 years.
• •3. Adequate organ function at screening.
• •4. Clinical laboratory values meet criteria at screening.
• •SLE:
• •Have been diagnosed of SLE at least 6 months before screening.
• •At screening, antinuclear antibody, and/or anti-dsDNA antibody, and/or anti-Smith antibody should be positive.
• •Fulfill relapsed/refractory SLE conditions.
• •AAV:
• •Have been diagnosed of AAV before screening.
• •Positive test for anti-PR3 or anti-MPO antibodies at screening.
• •Fulfill relapsed/refractory AAV conditions.
• •SSc:
• •Have been diagnosed of SSc before screening.
• •At screening, mRSS is higher than 10.
• •Fulfill relapsed/refractory SSc conditions.
• •IIM:
• •Have been diagnosed of IIM before screening.
• •Positive test for myositis-associated antibodies or myositis-specific antibodies at screening.
• •Fulfill relapsed/refractory IIM conditions.