Colangioids to Define the Genetic Factors Involved in Atypical Primary Sclerosing Cholangitis

Inclusion Criteria

• •Between 18 and 90 years of age
• •Of both sexes
• •willingness to sign informed consent for the study; Additional criteria group 1
• •Patients with a confirmed aPSC diagnosis Additional criteria group 2
• •patients with suspected PSC liver biopsy candidates Additional criteria group 3
• •Patients not affected by aPSC listed for the following procedures:
• •Liver resection for hepatocellular or other hepatic lesions (including secondary effects from other cancers and benign focal lesions, which will result in healthy liver tissue);
• •Post-transplant biopsies of healthy liver;
• •cholecystectomies. Additional criteria group 4
• •Patients previously genotyped in the study "Impact of complete exoma sequencing on clinical management of patient with non-alcoholic liver steatosis and cryptogenic liver disease project code RF-2016-02364358" results carrying gene variants associated with ciliopathies