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Post COVID-19 Syndrome Treatment With Variable Pulse Transcranial Magnetic Stimulation | Clinical Trials | Clareo Health

RECRUITINGNA

Post COVID-19 Syndrome Treatment With Variable Pulse Transcranial Magnetic Stimulation

Variable Pulse Transcranial Magnetic Stimulation for Treatment of Post COVID Syndrome

NCT06865222•Mayo Clinic

View on ClinicalTrials.gov

Summary

The purpose of this study is to test if Variable Pulse TMS (Transcranial Magnetic Stimulation) can result in objective improvements in patients with Post COVID Syndrome (PCS).

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients who have had a recent episode of COVID-19 and who present to the Post COVID-19 Clinic at Mayo Clinic Rochester with at least one of the PCC symptoms of interest - anosmia, tinnitus, fatigue. Symptoms consistent with PCC lasting at least 1 month after the positive test date. Subjects must have ongoing symptoms for \> 4 weeks following the start of an acute covid infection. This is consistent with the CDC definition for post covid conditions. Start date is determined by date of first positive COVID test. There is no limitation of maximum time from acute infection start.
•At least one of the PCC symptoms of interest:
•* Anosmia: Olfactory Threshold Test scores corresponding to Anosmia or Hyposmia
•* Tinnitus: \>0 score on Tinnitus Handicap Inventory (not present prior to SARS-COVID 2 infection)
•* Fatigue: Total Modified Fatigue Impact Scale (MFIS) Score of 40 or above

Exclusion Criteria

•Implanted electronic devices, including pacemakers, defibrillators, implant medication pumps, or vagus nerve stimulators (VNS)
•Active alcohol abuse: \>14 drinks a week or formal diagnosis, illicit drug use or drug abuse
•Any seizure history within the past 10 years
•Intracranial implant within 30 cm of magnet (e.g., aneurysm clips, endovascular coil, cerebral shunts, brain stimulators, cochlear implants, stents, or electrodes) or any other metal object within or near the head, excluding the mouth, which cannot be safely removed
•Enrolled or plans to enroll in an interventional trial during this study
•Previous stroke with residual deficits
•Subjects unable to comprehend or follow verbal commands
•Subjects unable to comprehend and sign the informed consent
•Based on PI's or local physician's assessment that subject unable to tolerate the trial procedure due to medical condition
•Clinical abnormality or clinically unstable medical condition, as indicated by medical history, physical examination, or clinical laboratory testing, that in the Investigator's judgment might pose a potential safety risk to the subject or limit interpretation of the trial results
+2 more criteria

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Key Dates

Start Date

July 22, 2025

Primary Completion Date

January 1, 2027

Completion Date

April 1, 2027

Last Updated

August 14, 2025

Enrollment

ESTIMATED participants

Conditions

Post COVID-19 Condition

Interventions

Electromagnetic Brain Pulsing Variable Pulse Protocol (EMBP) - 2 weeks

PROCEDURE

Electromagnetic Brain Pulsing Variable Pulse Protocol (EMBP) - 4 weeks

PROCEDURE

Contacts

Department of Medicine Research Hub, Coordinator

CONTACT

507-266-1944 domresearchhub@mayo.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 14, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Post COVID-19 Syndrome Treatment With Variable Pulse Transcranial Magnetic Stimulation

Inclusion Criteria

Exclusion Criteria

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