4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Inclusion Criteria

• •≥50 years of age at time of consent
• •Treatment naïve MNV secondary to nAMD in the study eye
• •Active subfoveal MNV or juxtafoveal/ extrafoveal MNV with a subfoveal component (where activity is defined as evidence of SRF, IRF, subretinal hyperreflective material, or leakage) identified by fluorescein angiography (FA) or spectral domain optical coherence tomography (SD-OCT), in the study eye, at the Screening Visit confirmed by the Reading Center
• •Demonstrated clinical response to aflibercept and functional stability in the study eye as confirmed by the Reading Center
• •BCVA between 25 and 78 ETDRS letters, inclusive (20/320-20/32 Snellen equivalent) in the study eye at the Screening Visit
• •CST less than or equal to 500 microns in the study eye at screening visit, confirmed by the central reading center