Pregnancy.

Significant bleeding risk (International Normalized Ratio (INR) \> 1.5 OR platelet count \< 50000).

Presence of active gastrointestinal bleeding at the time of screening

History of any blood thinner consumption (e.g. warfarin, heparin, novel roal anticoagulants) within the last 5 days.

Presence of massive ascites causing abdominal distension or requiring frequent therapeutic paracentesis.

Subjects having received previous Transjugular Intrahepatic Portosystemic Shunt (TIPS) or Surgical Portosystemic Shunt.

Hepatocellular carcinoma not meeting Milan Criteria.

Presence of portal vein thrombosis or another suspected component of presinusoidal portal hypertension.

Presence of extra-hepatic cancer, terminal disease, or severe comorbidities significantly limiting life expectancy or affecting study participation.

Stenosis or surgical anatomical alterations of the gastrointestinal tract that could preclude endoscopic access with the echoendoscope.

EUS-guided Portal Pressure Gradient (PPG) Measurement: a Potential Alternative to the Traditional HVPG