Stem Cell Therapy for Intracerebral Hemorrhage

Exclusion Criteria

• •1. Brain midline deviation \>10 mm or brain hernia formation.
• •2. Patients who have undergone or intend to undergo surgical treatment to remove hematoma.
• •3. Secondary intracerebral hemorrhage caused by traumatic brain injury, arteriovenous malformation, intracranial aneurysm, coagulation disorders, hemorrhagic transformation after cerebral infarction, or tumors.
• •4. Suffering from malignant tumors, autoimmune diseases (including but not limited to systemic lupus erythematosus, systemic vasculitis, etc.), hemorrhagic predisposition diseases (including all kinds of hereditary hemorrhagic disorders and acquired hemorrhagic diseases), malignant cardiac arrhythmia, cardiac insufficiency (BNP ≥1000pg/mL or left ventricular ejection fraction ≤40%), acute myocardial infarction, acute or severe infectious diseases (such as intracranial infection, severe pneumonia, sepsis, etc.) and other serious diseases that may aggravate the condition and affect the assessment of efficacy.
• •5. Allergy or intolerance to stem cell preparations or related medicines that need to be used in the infusion process, such as saline preparations and hormone preparations.
• •6. Pregnant or lactating women.
• •7. History of stroke disease with sequelae in the last 1 year, NIHSS score ≥ 6.
• •8. Subarachnoid hemorrhage, primary ventricular hemorrhage, pharmacological hemorrhagic stroke.
• •9. Unstable vital signs, including combined respiratory abnormalities (respiratory rate \<12 breaths/min or \>24 breaths/min, oxygen saturation ≤90%), hyperthermia (axillary temperature \>39 ℃), blood pressure ≥180/100 mmHg after antihypertensive treatment, blood glucose \>20 mmol/L.
• •10. Those who are participating in other clinical trials.
• •11. Previous history of epilepsy or current use of antiepileptic drugs.
• •12. Unable to accept all laboratory tests and imaging tests designed by the program due to metal implants or pacemakers in the body.
• •13. Inability to complete the follow-up program as required.
• •14. Patients or their legal guardians are unwilling to sign the written informed consent.