Loading clinical trials...

Therapeutic Effect of Upadacitinib in Primary Sjögren's Syndrome | Clinical Trials | Clareo Health

NOT_YET_RECRUITINGPHASE2

Therapeutic Effect of Upadacitinib in Primary Sjögren's Syndrome

Efficacy, Safety and Immunological Effect of Upadacitinib in the Treatment of Primary Sjögren's Syndrome

NCT06862284•Peking University People's Hospital

Summary

This study is designed to explore the efficacy and safety of upadacitinib and clarify the influence on immune function in the treatment of primary Sjögren's Syndrome.

Detailed Description

This is an open-label, single-center, randomized controlled trial of upadacitinib in the treatment of active primary Sjögren's Syndrome. The enrollment was based on the American College of Rheumatology(ACR) and European League Against Rheumatism (EULAR)(2016) diagnostic criteria. The efficacy and safety were evaluated in participants given upadacitinib 15mg/day and a proper, stable dose of hydroxychloroquine 400mg/day. Changes in clinical manifestation, laboratory indexes, and immunological indicators were explored in the process.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Male or female \>18 years of age at screening visits
•2. Participants with diagnosis of pSS according to the 2016 ACR/EULAR criteria
•3. Participants have an ESSDAI score ≥ 5
•4. Participants must be on a stable dose of prednisone (≤10mg/day), antimalarials or equivalent, and cholinergic stimulants prior to Baseline.
•5. Participants previously on other immunosuppressive drugs (methotrexate, azathioprine, mycophenolate mofetil, cyclosporine, tacrolimus, iguratimod) should have withdrawn drug for at least 8 weeks (56 days) at the time of screening
•6. If the subject has evidence of new latent tuberculosis (TB) infection, the subject must initiate and complete a minimum of 2 weeks (or per local guidelines, whichever is longer) of an ongoing TB prophylaxis before continuing to receive the study drug.
•7. If female, the subject must be postmenopausal, OR permanently surgically sterile, OR for women of childbearing potential practicing at least one protocol-specified method of birth control, that is effective from Study Day 1 through at least 30 days after the last dose of study drug.
•8. The patient must be informed in writing of the consent to participate in the trial and the patient is expected to be able to comply with the requirements of the study follow-up plan and other protocols.

Exclusion Criteria

•Any subject meeting any of the following criteria should be excluded:
•1. Pregnant or breastfeeding female.
•2. Diagnosis of other autoimmune disease, or other sicca syndrome.
•3. Laboratory value abnormality:
•(1)Serum aspartate transaminase (AST) or alanine transaminase (ALT) \> 3.0 × upper limit of normal (ULN); (2)Estimated glomerular filtration rate by simplified 4-variable Modification of Diet in Renal Disease (MDRD) formula \< 40 mL/min/1.73m\^2; (3)Total white blood cell count (WBC) \< 2,000/μL; (4)Absolute neutrophil count (ANC) \< 1,000/μL; (5)Platelet count \< 50,000/μL; (6)Absolute lymphocytes count \< 500/μL; (7)Hemoglobin \< 8 g/dL.
•4\. Ongoing infections at Week 0 that have not been successfully treated.
•5\. Infection with HIV ( HIV antibody positive serological test ) or hepatitis C ( hepatitis C antibody positive serological test ). If the serum reaction is positive, it is recommended to consult a doctor with expertise in the treatment of HIV or hepatitis C virus infection.
•6\. History of any known malignancy in the last 5 years (except non-melanoma skin cancer, non-melanoma skin cancer or cervical tumors that have not recurred within 3 months after surgical cure prior to screening).
•7\. Underlying cardiac, pulmonary, metabolic, renal, hepatic, gastrointestinal, hematological or neurological conditions, chronic or latent infectious diseases, or immune deficiency which places the patient at an unacceptable risk for participation in the study.
•8\. Prior exposure to any Janus kinase (JAK) inhibitor (including but not limited to tocilizumab, sirukumab, sarilumab, upadacitinib, tofacitinib, baricitinib, ruxolitinib, peficitinib, and filgotinib).
+3 more criteria

Locations (1)

Department of Rheumatology and Immunology, Peking University People's Hospital

Beijing, China, China

Key Dates

Start Date

March 10, 2025

Primary Completion Date

December 30, 2026

Completion Date

August 31, 2027

Last Updated

March 11, 2025

Enrollment

ESTIMATED participants

Conditions

Primary Sjögren's Syndrome (pSS)

Interventions

Upadacitinib (ABT-494)

DRUG

Hydroxychloroquine (HCQ)

DRUG

Contacts

Shiyu He

CONTACT

+86 19947570486 heshiyu@stu.pku.edu.cn

Jing He

CONTACT

+86 18611707347 hejing1105@126.com

Clinical Study to Investigate the Efficacy of Orally Administered SA001 in Patients With Primary Sjögren's Syndrome

NCT05269810

Primary Sjögren's Syndrome (pSS)

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 11, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions