Little Lungs Study

Exclusion Criteria

• •Major congenital anomalies including congenital lung malformations and congenital diaphragmatic hernia and/or genetic disorders
• •Alternative, acute clinical etiology of respiratory deterioration or increased ventilatory requirements (e.g., sepsis, pneumonia, etc.)
• •History of pulmonary hemorrhage
• •Antibiotic use within 48 hours
• •Indomethacin or Ibuprofen use within 72 hours
• •Prior treatment with corticosteroids for prevention of lung disease
• •Not expected to survive for greater than 7 days at enrollment
• •Determined to be unstable by the clinical team
• •Enrolled in a conflicting clinical trial
• •Have a birth parent aged less than 18 years
• •Parent/guardian is unable to provide parental permission in English or Spanish