Primary diagnosis of Major Depressive Disorder as determined by the study psychiatrist and confirmed by the Mini-International Neuropsychiatric Interview (MINI)
Lifetime suicide attempt history and suicidal ideation at baseline as determined by a score ≥2 on the Columbia-Suicide Severity Rating Scale (C-SSRS)
You may not be if
Clinically significant medical or neurological condition
Current use of strong CYP3A live enzymes or moderate CYP3A inhibitors or strong CYP3A inducers
Current use of digoxin
Currently pregnant, not using contraception, nursing, or trying to become pregnant
Active substance use disorder in the last six months, disorder, or current or past psychotic disorder, bipolar disorder, or obsessive-compulsive disorder
Severe traumatic brain injury
Imminent suicidal or homicidal risk
Free of unstable medical conditions or any contraindication to suvorexant (per FDA prescribing label) as determined by patient interview and review of available medical records.
Clareo Health | Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial
