Double Dose 4-AP on Functional Recovery After Spinal Cord Injury

Exclusion Criteria

• •Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease
• •Any history of renal impairment
• •Any debilitating disease prior to the SCI that caused exercise intolerance
• •Premorbid, ongoing major depression or psychosis, altered cognitive status
• •History of head injury or stroke
• •Vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, even without history of seizure, and without anticonvulsant medication
• •History of seizures or epilepsy
• •Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold (see appendix 2)
• •Pregnant females
• •If a women of child bearing age is unsure of the pregnancy, and does not want to take the pregnancy test
• •Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida, MS, or herniated disk
• •Metal plate in skull
• •Individuals with scalp shrapnel, cochlear implants, or aneurysm clips
• •Individuals taking Bupropion, Dolutegravir, Lacosamide, Trilaciclib, or PR Interval prolonging drugs