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Antibiotic Exposure on Gut Microbiota and Motility Establishment in Newborns | Clinical Trials | Clareo Health

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Antibiotic Exposure on Gut Microbiota and Motility Establishment in Newborns

Effects of Early Antibiotic Exposure on Gut Microbiota and Motility Establishment in Newborns: a Prospective Cohort Study

NCT06850896•The First Hospital of Jilin University

View on ClinicalTrials.gov

Summary

This prospective cohort study aims to investigate the impact of early antibiotic exposure on the establishment of gut microbiota and motility in newborns, particularly preterm infants. The study will explore the correlation between antibiotic exposure, gut microbiota colonization, and 5-hydroxytryptamine (5-HT) levels, which are critical for gastrointestinal motility. The findings may provide insights into optimizing antibiotic use and improving gastrointestinal health in neonates.

Eligibility

Age

0 - 0 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Newborns admitted within 72 hours of birth
•Gestational age 24-36 weeks (preterm) and term infants
•Informed consent obtained from parents or guardian

Exclusion Criteria

•Congenital gastrointestinal malformations (e.g., intestinal atresia, Hirschsprung's disease)
•Severe systemic or organ-specific diseases
•Expected mortality due to severe illness

Locations (1)

The first hospital of Jilin university

Changchun, Jilin, China

Key Dates

Start Date

February 1, 2025

Primary Completion Date

May 30, 2027

Completion Date

May 30, 2027

Last Updated

February 28, 2025

Enrollment

200

ESTIMATED participants

Conditions

NEC - Necrotizing Enterocolitis

Targeted vs Standard Fortification of Breast Milk

NCT03775785

BPD - Bronchopulmonary DysplasiaNEC - Necrotizing Enterocolitis+3 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 28, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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