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Effects of Light vs. Heavy Paraffin Oil on Embryo Culture in IVF: A Prospective Study on Development and Pregnancy Rate | Clinical Trials | Clareo Health

COMPLETEDNA

Effects of Light vs. Heavy Paraffin Oil on Embryo Culture in IVF: A Prospective Study on Development and Pregnancy Rate

NCT06838923•Hung Vuong Hospital

View on ClinicalTrials.gov

Summary

This prospective study aims to compare the effects of light and heavy paraffin oil in embryo culture during in vitro fertilization (IVF). Paraffin oil is commonly used in IVF laboratories to protect embryo culture media from evaporation and temperature fluctuations. However, the impact of different oil viscosities on embryo development and pregnancy outcomes remains unclear. Participants undergoing IVF treatment will have their embryos cultured under either light or heavy paraffin oil conditions. The study will evaluate key outcomes, including embryo development, blastocyst formation rates, and pregnancy rates. Findings from this research may help optimize embryo culture conditions, potentially improving IVF success rates and guiding best laboratory practices.

Eligibility

Age

18 - 45 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•Women undergoing in vitro fertilization (IVF) treatment with planned embryo culture.
•Patients with normal ovarian function or undergoing ovarian stimulation for IVF.
•Willingness to participate and provide informed consent.

Exclusion Criteria

•Presence of severe uterine abnormalities (e.g., congenital malformations, Asherman's syndrome).
•History of recurrent implantation failure (≥3 unsuccessful IVF attempts).
•Poor ovarian response (e.g., ≤3 oocytes retrieved in a previous IVF cycle).
•Presence of severe male factor infertility, requiring testicular sperm extraction (TESE) or micro-TESE.
•Use of pre-implantation genetic testing (PGT) for embryo selection.
•Known autoimmune disorders or uncontrolled chronic conditions (e.g., diabetes, thyroid disorders) that may affect pregnancy outcomes.
•Participation in another clinical trial that may interfere with study outcomes.
•Donor cycles or surrogacy.

Locations (1)

Hung Vuong Hospital

Ho Chi Minh City, Vietnam

Key Dates

Start Date

May 23, 2023

Primary Completion Date

December 31, 2023

Completion Date

January 15, 2025

Last Updated

February 21, 2025

Enrollment

818

ACTUAL participants

Conditions

Embryo DevelopmentBlastocyst IVFPregnancy RatesIVFEmbryo Culture Media

Interventions

Light Paraffin Oil

COMBINATION_PRODUCT

Heavy Paraffin Oil

COMBINATION_PRODUCT

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Infertility TreatmentPregnancy Rates

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COMPLETEDNA

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Effect on Implantation and Pregnancy Rates

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 21, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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