Drug Interactions Trial of Methoxyethyl Etomidate Hydrochloride

Exclusion Criteria

• •\-
• •Auxiliary examination:
• •1. if the results of physical examination, vital signs, 12-lead electrocardiogram, cortisol test, and laboratory tests are abnormal and clinically meaningful;
• •2. potentially difficult airway;
• •3. hepatitis B surface antigen, hepatitis C antibody, HIV antibody or syphilis antibody positive;
• •Medication history:
• •4. use of any drugs that inhibit or induce hepatic drug-metabolizing enzymes within 30 days before screening;
• •5. use of any prescribed medication within 14 days before dosing;
• •6. use of over-the-counter drugs, Chinese herbal medicines or food supplements such as vitamins and calcium supplements within 7 days before administration;
• •History of disease and surgery:
• •7. any history of clinically severe illness or any disease or condition that the investigator believes may affect the trial results;
• •8. patients with a history of adrenal insufficiency, adrenal tumors, or hereditary heme biosynthesis disorders;
• •9. a history of severe cardiovascular disease, including but not limited to a history of organic heart disease, such as heart failure, myocardial infarction, angina, malignant arrhythmia, such as a history of torssion ventricular tachycardia, ventricular tachycardia, long QT syndrome, or symptoms of long QT syndrome and family history;
• •10. underwent any surgery within 6 months before screening;
• •11. allergic constitution; Or who, as judged by the investigator, may be allergic to the trial drug or its excipients;
• •Living habits:
• •12. heavy drinking or regular drinking in the 6 months before screening, i.e. drinking more than 14 units of alcohol per week (1 unit =360 mL of beer or 45 mL of 40% spirits or 150 mL of wine); Or with a positive alcohol breath test at baseline;
• •13. smoked more than 5 cigarettes per day in the 3 months before screening or could not quit smoking during the study;
• •14. had a history of drug abuse or drug abuse within 3 months before screening; Or the baseline urine drug test was positive;
• •15. habitual consumption of grapefruit juice or excessive tea, coffee, and/or caffeinated beverages and inability to quit during the trial;
• •Others:
• •16. those who have difficulty in blood collection, can not tolerate venipuncture or arterial blood collection;
• •17. participated in any other clinical trial within 3 months before screening;
• •18. vaccinated within 1 month before screening or planned to be vaccinated during the trial period;
• •19. pregnant or lactating women;
• •20. childbearing or sperm donation plan during the trial and half a year after the completion of the trial, or do not agree that the subjects and their spouses should take strict contraceptive measures during the trial and half a year after the completion of the trial;
• •21. had blood loss or donation \>400 mL within 3 months before screening, or received blood transfusion within 1 month;
• •22. subjects with any factors considered by the investigator to be ineligible for the trial.