Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Texas at Austin
With
Roots Behavioral Health
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Adults aged 18-65 years diagnosed with LC and possess a documented history of positive COVID-19 diagnostic testing or a probable infection as determined by a healthcare provider.
One persistent symptom of fatigue or neurocognitive dysfunction as defined by rating their symptoms as moderate to severe on the screening form.
English as a primary language OR comprehension of English suitable to understand research staff instructions.
All participants must be eligible for MRI and will undergo MRI scans pre- and post-treatment
You may not be if
Contraindications to ketamine therapy:
Current substance use disorder
Current mania or psychosis
Recent myocardial infarction or stroke (within 1 year)
Recent COVID-19 infection or reinfection within 8 weeks
Prior receipt of ketamine treatment
History of treatment resistant depression (TRD) prior to development of LC
* Defined as completing a trial (2 months of treatment at highest tolerated dose) of 3 or more psychotropic medications from at least 2 classes of medications (i.e. SSRIs, SNRIs, antipsychotic medications, or mood stabilizers such as lithium, lamotrigine, Depakote, or oxcarbazepine)
* Psychotropic medications used during treatment of LC will not be counted as medications used for TRD
Current severe depression or anxiety, and/or active suicidal ideation
* Severe depression and anxiety defined as scoring \> 19 on PHQ-9 screening or \> 14 on GAD-7 screening.
* Active suicidal ideation is defined as answering "yes" to question #9 on the PHQ-9
History of bipolar disorder, schizophrenia, or schizoaffective disorder
History of suicide attempt or psychiatric hospitalization for any reason in the last 5 years
Current benzodiazepine or naltrexone medication use within 4 weeks of enrollment as these may decrease or block the therapeutic effect of ketamine treatment
