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Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation | Clinical Trials | Clareo Health

RECRUITINGNA

Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation

Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation in Patients with Multiple Sclerosis

NCT06820125•Universita di Verona

Summary

The first aim of this project is to investigate the effects of different high-tech neurorehabilitation interventions (cognitive, motor, and combined cognitive-motor) on both cognitive and motor disability outcomes in people with multiple sclerosis (MS). The second aim is to identify the cognitive and motor profiles of MS patients who benefit the most from either the combined cognitive-motor rehabilitation intervention or the isolated cognitive or motor treatments.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•presence of mild (one or two neuropsychological tests below the cut-off score, 5th percentile) or severe (more than two neuropsychological tests below the cut-off score, 5th percentile) cognitive impairment,
•mild to moderate walking disability with Expanded Disability Status Scale (EDSS) between 3 and 6,
•no relapse or associated steroid use in the past three months,
•adequate visual and auditory capacity to operate computer software.

Exclusion Criteria

•presence of other neurological disorders than MS,
•major psychiatric disorders,
•high levels of anxiety and/or depression (score\>20 for Depression scale and up to 14 for Anxiety scale on Italian adaptation of the Depression, Anxiety and Stress Scale (DASS-21),
•substance abuse,
•any type of rehabilitation intervention in the month prior to recruitment
•pharmacological therapy not well defined and/or changed during the study
•presence of paroxysmal vertigo
•lower limb botulinum toxin injections within the previous 12 weeks

Locations (1)

Sezione medicina fisica e riabilitativa dipartimento di neuroscienze

Verona, verona, Italy

Key Dates

Start Date

July 5, 2023

Primary Completion Date

July 5, 2023

Completion Date

July 5, 2026

Last Updated

February 11, 2025

Enrollment

ESTIMATED participants

Conditions

RehabilitationMultiple SclerosisCognitive DeficitMotor Deficits

Interventions

Cognitive rehabilitation: CG group

DEVICE

Motor rehabilitation: MG group

DEVICE

Combined rehabilitation: CbG group

DEVICE

Contacts

Valentina Varalta

CONTACT

045 8124956 valentina.varalta@univr.it

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 11, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation

Inclusion Criteria

Exclusion Criteria

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