Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
NYU Langone Health
Age
25–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Female
Age 25-65 years (inclusive)
Definite diagnosis of MS or related demyelinating disorders (e.g., Neuromyelitis Optica or NMO)
Stable high efficacy DMT ≥ 6 months before enrollment and throughout the trial
PDDS score ≤ 6 (established to be able to complete procedures)
SymptoMScreen Score ≥12
WRAT-5 ≥85
SDMT z-score \> -3.0
K10 \< 35
Stable disease activity, defined as being more than 1 month after a clinical relapse or confirmed radiologic disease activity, or more than 1 month after steroid treatment
Ability to use mobile devices
You may not be if
Primary neurologic disorder other than MS and related demyelinating disorders like NMO (e.g., stroke, Parkinson's disease, spinal cord injury, intracranial mass, traumatic brain injury (TBI), epilepsy, mild cognitive impairment (MCI), or dementia), psychiatric disorders or major medical disorders (e.g., history of myocardial infarction, diabetes, thyroid disease, arrhythmia, atrial fibrillation)
Diagnosis of Postural Orthostatic Tachycardia Syndrome (POTS)
History of vagus nerve surgery/vagotomy
History of diagnosed cardiovascular disease, a heart transplant, presence of permanent pacemaker implant or Left Ventricular Assist Device
Use of certain medications that can affect heart rate variability, such as beta-blockers, calcium channel blockers, and cardiac glycosides
Use of SP1 inhibitor medications such as Fingolimod, Siponimod, Ozanimod, and Ponesimod
Nicotine use in the past 6 months (smoking/vaping)
Pregnant or planning pregnancy during the study period or breastfeeding
Seizure disorder or recent (\<5 years) seizure history
Active ear infections or ear pathology
Current presence of implanted vagus nerve stimulator or any other active implanted electronic devices (e.g., pacemaker, defibrillators, cochlear implants, DBS, iVNS, etc.)
Presence of metal objects in the head/neck
Any skin disorder or skin sensitive area near stimulation locations
