Physiological Effects of Nebulized Salbutamol in Acute Respiratory Failure Patients on HFNC

Exclusion Criteria

• •• Age \< 18 years
• •* Hypercapnia (PaCO2 \> 50 mmHg)
• •* Hemodynamic instability (Systolic blood pressure \< 90 mmHg or Mean arterial pressure \< 60 or high dose of vasoactive drugs)
• •* Tachycardia or tachyarrhythmia (HR \> 130 b/min)
• •* Known allergy or intolerance to salbutamol
• •* Patient has received inhaled therapy with short-acting beta 2 agonists \< 8 hours before or with long-acting beta 2 agonists \< 24 hours before
• •* Acute exacerbation of COPD or bronchial asthma
• •* Cardiogenic pulmonary edema
• •* GCS ≤ 12
• •* Contraindication for EIT (e.g. ICD)
• •* Pregnancy
• •* Patient refuses to participate