GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma

The study team will collect up to 180 mL (approximately 12 tablespoons) of participants blood. This will be used to grow T cells. The study team grows the T cells and uses a retrovirus (a special virus that can insert the GPC3 CAR and IL15 genes into the T cells) to genetically engineer them. After the CAR and IL15 genes were put into the T cells, the study team ensures that they could kill GPC3 positive solid tumor cells in the laboratory. WHAT THE TREATMENT WILL BE LIKE: After making these cells, they were frozen. If the participant agrees to participate in this study, at the time they are scheduled to be treated, the cells will then be thawed and administered in the participants tumor area, called an intracavitary administration, during the participants already scheduled surgical resection. The participant will only get one dose of GO-CART T cells. The participant may be pretreated with Tylenol (acetaminophen) and Benadryl (diphenhydramine). Tylenol and Benadryl are given to prevent a possible allergic reaction to the T cell administration. In addition to the GO-CART T cell treatment, during surgery the surgeon will place a small device called an Ommaya reservoir. This device consists of a small tube approximately 3 millimeters in diameter whose tip will sit in the normal fluid filled spaces in the participants brain (called the ventricles). The other end of the tube will be attached to a small reservoir that will sit underneath the participants scalp. Ommaya reservoirs are commonly placed in cancer participants to treat participants with cancer cells in the cerebrospinal fluid and pose a low risk of complications. The purpose of this reservoir is to help reduce the pressure in the participants brain should they experience this from the treatment which is an unlikely but reported side effect . The reservoir will also be used to monitor the participants response to the study treatment rather than to administer treatment. This is a dose escalation study, which means that the study team does not know the highest dose of GO-CART T cells that is safe. To find out, the cells will be given to at least 3 participants at a lower dose. If that is safe, the study team will raise the dose level that is given to the next group of participants. The dose a participant received will get will depend on how many participants get the agent before the participant and how they react. The investigator will tell the participant this information. Since the treatment is experimental, what is likely to happen at any dose is not known. All the treatments will be given by the Center for Cell and Gene Therapy at Baylor St. Luke's Medical Center. Medical tests before treatment: Before being treated, the participant will receive a series of standard medical tests: * Physical exam and history * Blood tests to measure blood cells, kidney and liver function. * Pregnancy test (if the participant is a female who can get pregnant) * If the participant is infected with the hepatitis B virus (HBV) the study team will do a test to measure the levels of the virus * Measurements of the participants tumor by scans (either CT or MRI). Side effects are rare and include risk of developing an unrelated cancer due to radiation exposure from the machine, but this is unlikely. Medical tests during and after treatment: The participant will receive standard medical tests when they are getting the infusions and after: * Physical exams and History * Blood tests to measure blood cells, kidney and liver function. * If the participant is infected with the hepatitis B virus (HBV) the study team will repeat the test and monitor the levels of the virus * Cerebral spinal fluid collections to monitor for any side effects during the course of the treatment * Measurements of the participants tumor by scans (1 week, and 4 - 6 weeks after the treatment) FOLLOW-UP STUDIES: The study team will follow the participant during and after the injections. To learn more about the way the T cells are working in the participants body, up to 60 mL (up to 12 teaspoons, no more than 3mL/kg/day) of blood will be taken before the chemotherapy, before the T-cell infusion, 1 to 4 hours after the infusion, 3 to 4 days after the infusion (this time point is optional) at 1 week, 2 weeks, 3 weeks, 4 weeks and 8 weeks after the injection, every 3 months for 1 year, every 6 months for 4 years and then every year for the next 10 years. Total participation time for this study will be 15 years. During the time points listed above, if the T cells are found in the participants blood at a certain amount an extra 5mL of blood may need to be collected for additional testing. The study team will use this blood to look for the frequency and activity of the cells that have been given ; that is, to learn more about the way the T cells are working and how long they last in the body. The study team will also use this blood to see if there are any long-term side effects of putting the new gene (chimeric antigen receptor, CAR) into the cells. In addition to the blood draws, because the participant has received cells that have had a new gene put in them, they will need to have long term follow up for 15 years to see if there are any long-term side effects of the gene transfer. Once a year, the participant will be asked to have their blood drawn and answer questions about their general health and medical condition. The study team may ask the participant to report any recent hospitalizations, new medications, or the development of conditions or illness that were not present during enrollment in the study and may request that physical exams and/or laboratory tests be performed if necessary. If the participants tumor requires further surgery after the study treatment, for clinical reasons the study team will request permission to obtain excess sample to learn more about the effects of the treatment on the participants disease. In the event of death, the study team will request permission to perform an autopsy to learn more about the effects of the treatment on the participants disease and if there were any side effects from the cells with the new gene. In addition, the study team will ask for the participants permission to use tumor biopsy for research purposes only. Associated risk with the biopsy will be discussed with the participant in detail in a procedure specific consent form. The study team will test the sample to see if the GO-CART T cells can be found in the tumor and what effect they had on the tumor cells. If the participant develops a second abnormal cancer growth, significant blood or nervous system disorder during the trial, the study team will request that a biopsy sample of the tissue will be tested. The remaining blood and/or tissue samples that are not needed directly for the participant could be used to help researchers learn about this disease and/or immune therapy. These specimens and information about the participants circumstances may be shared with other cancer researchers. Although there will be a record identifying under what circumstances these specimens were obtained, under all circumstances the participants identity will be kept confidential. There is a small risk for the loss of confidentiality. However, study personnel will make every effort to minimize this risk. Samples will be kept at Baylor College of Medicine until they are exhausted.